[PREVIEW] A Saturday morning that changed everything...

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Hello everyone and welcome to PharmaMinds,

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the podcast that takes you behind the scenes with the leading figures in the pharma world.

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New week,

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new episode,

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and here's a sneak peek of the conversation you can catch online starting tomorrow.

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But you know what,

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it was actually a Saturday morning and

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I said,

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you know,

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please text me when I need to come in.

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So he texts me and on the text,

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there was actually nothing except,

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you know,

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sunshine.

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So I thought that's

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probably a good sign that means we made a statistical significant outcome.

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But what I didn't know is how shiny would be the sun.

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And so when I came in,

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he showed me with the team the results.

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And what was again,

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what was amazing is our placebo corrected effect was 16%

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in those two studies compared to 12%

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in the phase 2b.

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So in other words,

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we had a more efficacious drug in phase three than in phase two.

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And in the history of drug development,

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that happens very,

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very rarely.

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So

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I don't have the statistics,

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but it's extremely rare.

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So the level of surprise was beyond expectation because I thought the best case was 12%

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to be pretty much at the same level of the phase it has to be because that was part of the changes we made to in the design of the phase three,

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but we had over,

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you know,

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basically overpassed any expectations.

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So it was fantastic.

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And then on the safety side,

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it didn't seem to have,

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you know,

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really material adverse events that would...

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Same as you...

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Yeah,

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pretty much the same as...

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We saw,

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you know,

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some headaches,

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you know,

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early on the first week.

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But the last,

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you know,

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couple of days,

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you take Tylenol and you're all good.

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And the rest was,

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there was no incidence of really any...

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major manifestation of side effects on anything.

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So I mean,

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there are obviously some one-off patients that develop certain conditions,

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but there were no signals of anything.

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So it was just an absolutely incredible time.

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And then as a result,

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so I called my CFO,

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I called my head of IR,

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I said,

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initially,

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we had planned to take a week to review the data,

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you know,

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to prepare another thing and do basically the financial communication the following weekend.

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And what we did is we accelerated everything.

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I said,

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we need to have a board meeting,

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you know,

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on Sunday night.

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So we,

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you know,

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so within a day we had to put all the slides together,

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people who are literally day and night.

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And we did the communication on,

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you know,

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essentially on

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Monday night.

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And on Tuesday,

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the stock was traded.

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We actually blocked respectively for

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45 minutes,

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the

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Euronext, our quotation on Euronext,

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because it was too much demand.

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And then when the Nasdaq opened,

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the same thing happened.

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I think it was a bit less,

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30 minutes.

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You know,

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there was too much demand on the stock,

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and the stock went up that day by 600%.

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And 600%,

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you know,

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no stock on the Nasdaq has ever done that.

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So it was,

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I mean,

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for us,

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it was like,

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you know,

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it's like a Hollywood movie,

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you know.

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Is it true?

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If you enjoyed this snippet,

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remember to subscribe on this app and turn on the notifications to be the first to know when the full episode is out.

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Wishing you a fantastic listening experience and I'll see you soon on PharmaMinds.